Yes, it is really hard to find a cure for some disease. HIV is an example. some viruses are really complex. Sometimes there is less work done on research on rare diseases. This is not because nobody cares about the patients that have a rare disease, but if we take Motor Neurone Disease as an example and compare that to Multiple Sclerosis, there are about 360 people living with Motor Neurone Disease at any one time in Ireland and about 6,000 people living with MS. So though research into both diseases is occurring, fundraising for Motor Neurone Disease is more difficult because there are fewer people affected by it.
Yes! To speak about my own field, bacteria become resistant to antibiotics all the time in nature. The problem is that misuse of antibiotics (e.g. taking antibiotics when your sore throat is caused by a virus, or by regularly feeding antibiotics to farm animals to enhance their growth, which by right shouldn’t happen at all in Ireland…) seems to be accelerating this process. So even if new antimicrobial therapies are discovered, bacteria may become resistant to these quicker than new drugs can be discovered (a so-called microscopic arms race!)
Depends on how much you really know about the disease, in most cases we may be lacking enough information to find a proper cure. Some times there may be too many factors and zeroing the right ones may not be easy.
Other times one treatment may work in one patient while fail in other so it’s complicated to find a universal cure.
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