If a purine were substituted for a pyrimidine at a single position in one strand of a DNA double helix, what would

Question: If a purine were substituted for a pyrimidine at a single position in one strand of a DNA double helix, what would happen?
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Asked by wan of the wans to Ruth on 9 Nov 2015.
- Ruth Hamill answered on 9 Nov 2015:
  
  If it only happened on one strand, it would lead to a mismatch, the repair mechanisms would kick in and try to repair it. Most of the time this would be successful.

Question: If a purine were substituted for a pyrimidine at a single position in one strand of a DNA double helix, what would happen?